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Data availability Atomic coordinates and structure factors for the crystal structures of the TRF1 TRFH domain in complex with the compounds discussed herein have been deposited in the Protein Data Bank (www.wwpdb.org) and can be accessed using the PDB accession numbers provided in Supplementary Table 3

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HNF47-overexpression and control HGC-27 cells (stably expressing luciferase, 1 10 7 per mouse) were respectively injected into the abdominal cavity of nude mice, and the peritoneal metastasis was detected 30 days later using bioluminescence analysis

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Oxalate transport via the sulfate/HCO 3 exchanger in rabbit renal basolateral membrane vesicles